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KMID : 0377619670120040387
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Korean Jungang Medical Journal
1967 Volume.12 No. 4 p.387 ~ p.391
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Studies on the Cold Hemagglutination in Sera of VDRL-positive and Negative Groups
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金永洙/Kim, Young-Soo
尹秉文/李楨浩/全東雨/李相碩/金鍾建/Yun, Byung-Moon/Chun, Dong-Woo/Lee, Sang-Suk/Kim, Chong-Keun/Kim, Chin-Wook
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Abstract
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It had been known for many years that the mammalian tissue lipoidal antigen can stimulates the production of the reagin antibody-like substance which is nonspecific in nature it may elicit false positive cardiolipin complement fixation and microflocculation tests for a number of diseases unrelated to syphilis. Among the more common of these are upper respiratory infections, small pox vaccination, infectious mononucleosis, primary atypical pneumonia, measles and lymphogranuloma venereum. The highest percentages of biologic false positive reactions occur in malaria and leprosy. With the exception of leprosy, in these diseases are transitory and revert to the negative stage within a period of days, weeks or months to the serological tests for syphilis.
Moore and Mohr pointed out that in about 20 percent of biologic false positive reactions for syphilis in primary atypical pneumonia population. Cold hemagglutination were studied by authors on sera of Korean women (Age: 20 to 30, one hundred forty two VDRL positive and 411 VDRL negative sera) and obtained the following results.
1. No case of cold hemagglutinin was showed in VDRL positive group of 142 sera.
2. Only one case in 411 cases of VDRL negative group showed the presence of cold hemagglutinin at refrigerator temperature but the agglutinated erythrocytes redisperse when warmed and reagglutinate when again cooled.
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